Konsumsi Tahu Kedelai Hitam untuk Memperbaiki Nilai SGOT/ SGPT dan Aktivitas Antioksidan Plasma Penderita Diabetes Tipe 2

Main Article Content

Fransiska Rungkat Zakaria
Delina Puspa Rosana Firdaus
Nancy Dewi Yuliana

Abstract

Type 2 diabetes mellitus pathogenesis is characterized by high blood glucose which can be triggered by several factors such as oxidative stress, unhealthy diet, and poor lifestyle. The high content of bioactive components and low content of digestible carbohydrate in black soybeans tofu might contribute to the body antioxidant supply and control blood glucose levels. This study aimed to evaluate the effects of black soy tofu consumption toward plasma SGOT/SGPT and antioxidant capacity. The intervention of black soybean tofu was conducted for 28 days in 15 type-2 diabetic respondents. The results showed that black soybean tofu significantly (p ˂ 0.05) increased plasma antioxidant activity level of respondents, from 45.79 ± 3.31 percent to 53.05 ± 4.44 percent. SGOT / SGPT tests showed a decrement ((p ≥ 0.05), from 14.27 ± 3.81 / 21.07 ± 6.73 (U/L) to 12.73 ± 2.34 / 18.60 ± 4.29 (U/L). The processing of black soybeans into tofu caused a decrease in antioxidant activity, from 144.06 mg AEAC to 45.27 mg AEAC and the total anthocyanin, from 12.27 mg to 1.805 mg/100 g. The results suggested that black soybean tofu improved the health profile of the diabetic respondents by increasing plasma antioxidant capacity and decreasing plasma SGOT/SGPT level.

Article Details

Section
Articles
Author Biographies

Fransiska Rungkat Zakaria

Departemen Ilmu dan Teknologi Pangan, Fakultas Teknologi Pertanian, Institut Pertanian Bogor (IPB).

Delina Puspa Rosana Firdaus

Alumni Departemen Ilmu dan Tenologi Pangan, Fakultas Teknologi Pertanian, IPB

Nancy Dewi Yuliana

Departemen Ilmu dan Teknologi Pangan, Fakultas Teknologi Pertanian, Institut Pertanian Bogor (IPB).

References

[AOAC] Association of Analitycal Communities. 2005. Total monomeric anthocyanin pigment content of fruit juices, beverages, natural colorants, and wines [Internet]. [diunduh 2015 Juni 26]. Tersedia pada http://www.aoac.org/vmeth/omamanual/omamanual.htm

Ali N. 2011. Diabetes and You: A Comprehensive, Holistic Approach. Maryland (UK): Rowman & Littlefield Publisher.

Amirudin R. 2009. Fisologi dan biokimia hati. Dalam: Buku Ajar Ilmu Penyakit Dalam. Jakarta (ID): Interna Publishing.

Arnnok P, Ruangviriyachai C, Malachai R, Techawongstien S, Chanthai S. 2012. Determination of total phenolics and anthocyanin contents in the pericarp of hot chilli pepper (Capsinum annuum L.). Intern. Food Research J. 19: 235–243.

[BPS] Badan Pusat Statistik. 2015. Rata-rata konsumsi per kapita semiggu beberapa macam bahan makanan penting, 2007-2014 [Internet]. [diunduh 2015 Oktober 10]. Tersedia pada http://www.bps.go.id/linkTabelStatis/view/id/950.

Chao M, Zou D, Zhang Y, Chen Y, Wang M, Wu H, Ning G, Wang W. 2009. Improving insulin resistance with traditional Chinese medicine in type 2 diabetic patients. Endocrine. 36(2):268–274.

Choung MG, Kim JM, Kim JS, Yoo H, Sung MK. 2008. Effects of black soybean [Glycine max (L.)Merr.] seed coats and its anthocyanidins on colonic inflammation and cell proliferation in vitro and in vivo. J. Agric. Food Chem. 56: 8427–33.

[FAOSTAT] Food and Agriculture Organization of Statistic. 2005. Statistical data of food balance sheet [Internet]. [diunduh 2014 Desember 14]. Tersedia pada www.fao.org.

He FJ, Chen JQ. 2013. Consumption of soybean, soy foods, soy isoflavones and breast cancer incidence: Differences between Chinese women and women in Western countries and possible mechanisms. Food Scie and Human Wellness. 2: 146–161. Doi: 10.1016/j.fshw.2013.08.002.

Hung YH, Huang HY, Chou CC. 2007. Mutagenic and antimutagenic effects of metanol extracts of unfermented and fermented black soybeans. Int. J. Food Microbiol. 118: 62–68.

Jati IRAP, Vadivel VHK. 2013. Antioxidant activity of anthocyanins in common legume grains. In: Biesalski Bioactive Food as Dietary Interventions for Liver and Gastrointestinal Disease. Doi:10.1016/B978-0-12-397154-8.00007-5.

Lee JH, Kang NS, Shin SO. 2009. Characterisation of anthocyanins in the black soybean (Glycine max L.) by HPLC-DAD-ESI/MS analysis. Food Chemistry. 112:226–231.

Lin,C, Chou CC. 2009. Effect of heat treatment on total phenolic and anthocyanin contents as well as antioxidant activity of the extract from fermented black soybeans, a healthy food ingredient International J. of Food Sciences and Nutrition. 60(7): 627–636 doi: 10.3109/09637480801992492.

Mahaboob SR, Jayarami RU, John BS. 2013. A study on serum enzyme levels in various liver health conditions. Int J. Med Res Health Sci. 2(3):395-398.

Masella R, Di Benedetto R, Vari R. 2005. Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes. J Nutr Biochem. 5(16):577–586.

Muchtadi D. 2010. Kedelai Komponen Untuk Kesehatan. Bandung (ID): Alfabeta.

[PERKENI] Perkumpulan Endokrinologi Indonesia. 2011. Konsesus Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 di Indonesia.

Quassinti L, Bramucci M, Lupidi G, Barboni L, Ricciutelli M, Sagratini G, Papa F, Caprioli G, Petrelli D, Vitali LA, Vittori S, Maggi F. 2013. In vitro biological activity of essential oils and isolated furanosesquiterpenes from the neglected vegetable Smyrium olusatrum L. J. Food Chemistry. 138: 808-813.

Rahimi R, Nikfar S, Larijani B. 2005. A review on the role of antioxidants in the management of diabetes and its complications. Biomed Pharmacothe. 59:365–73.

Rodrigues GR, Porawski M, Marcolin E, Kretzmann AN, Falcao Ferraz A, Richter MF. 2012. Treatment with Aqueous Extract from Croton cajucara Benth Reduces Hepatic Oxidative Stress in Streptozotocin-Diabetic Rats. J. Biomed. 2012:1–7

Shih MC, Yang KT, Kuo SJ. 2002. Quality and antioxidative activity of black soybean tofu as affected by bean cultivar. J. of Food Science. 67: 480–484.

Tjokroprawiro A, Setiawan PB, Santoso D, Soegiarto G. 2007. Buku Ajar Ilmu Penyakit Dalam. Surabaya (ID): Airlangga University Press.

[USDA] United States Department of Agriculture. 2015. Statistics Report 16126, Tofu, firm, prepared with calcium sulfate and magnesium chloride (nigari) [Internet]. [diunduh 2015 Oktober 10]. Tersedia pada ndb.nal.usda.gov/ndb/foods/show/4838?format=Stats&reportfmt=pdf&pdfQvs=%7B%7D.

Wallace TC, Giusti MM. 2013. Anthocyanins in Health and Disease. Florida (US): CRC Press.

[WHO] World Health Organization. 2014. Country and regional data on diabetes [Internet]. [diunduh 2014 Des 14]. Tersedia pada www.who.int.

Xu B, Chang K. 2008. Total phenolics, phenolic acids, isoflavones, and anthocyanins and antioxidant properties of yellow and black soybeans as affected by thermal processing. J. Agric. Food Chem. 56:7165–7175.

Xu BJ, Chang SKC. 2007. A comparative study on phenolic profiles and antioxidant activities of legumes as affected by extraction solvents. J. Food Sci. 72 (2):159-166. doi: 10.1111/j.1750-3841.2006.00260.x.

Zakaria-Rungkat F, Adawiyah D, Irwanto R, Hasrini R. 2015. Pengembangan dan pemanfaatan produk berbasis kedelai hitam untuk pencegahan dan pengendalian diabetes. Laporan penelitian tahun ke 2. LPPM. IPB

Zakaria-Rungkat, F. 2015. Pangan Nabati, Utuh dan Fungsional sebagai Penyusun Diet Sehat. Orasi Ilmiah GB. IPB Press

Zakaria-Rungkat, F., Nurahman, Prangdimurti, E., Tejasari. 2003. Antioxidant and Immunoenhancement Activities of Ginger (Zingiber officinale Roscoe) Extracts and Compounds in In Vitro and In Vivo Mouse and Human System. Nutraceuticals and Foods.8; 96-104